Labour's National Executive Committee (NEC) agreed to allow the mayor of Greater Manchester to contest the seat.
A Labour Party spokesperson said: "Labour's ruling body, the National Executive Committee has today given permission to Andy Burnham to stand in the candidate selection process in the forthcoming by-election for the Makerfield constituency."
Mr Burnham, who dodged questions when he was spotted jogging by Sky News on Friday, has already confirmed his intention to stand in the by-election after the current MP, Josh Simons, announced he would quit parliament to make way for Mr Burnham.
Mr Burnham said he has wanted to "bring the change we have brought to Greater Manchester to the whole of the UK and make politics work properly for people".
Starmer latest: Andy Burnham clears hurdle in by-election bid
Mr Burnham previously wanted to stand as the Labour candidate in the Gorton and Denton by-election but his bid was blocked by the NEC.
Applications for the candidate selection process close on Monday and the NEC will endorse a candidate on Thursday.
It is thought that the earliest date the by-election near Greater Manchester could take place is 18 June.
If he is successfully elected, Mr Burnham is widely expected to challenge Sir Keir for the party leadership.
Labour expects a stiff challenge from Reform UK in Makerfield, with Mr Simons securing a majority of just 5,399 over Nigel Farage's party at the 2024 general election.
Since then, Labour's polling collapse and Reform's surge have seen their positions reverse.
This month's May elections saw Reform win every council ward in the Makerfield constituency, securing around half the vote, while Labour won only a little more than a quarter.
Read more:
Are all roads leading Labour to Andy Burnham?
Beth Rigby: Is the leadership race on?
Allies of Wes Streeting have told Sky News' Ali Fortescue that he will stand in any future Labour leadership contest.
It followed his resignation as health secretary on Thursday, when he delivered an explosive letter to Sir Keir accusing his government of "drift" and the PM himself of leaving a leadership "vacuum".
However, he did not trigger an immediate leadership contest himself as expected, calling instead for a "broad" debate about the party's future.
He also said he backed Mr Burnham to be the candidate in the upcoming by-election.
In a post on X, the now-former health secretary wrote: "We need our best players on the pitch. There is no doubt that Andy Burnham is one of them.
"The Makerfield by-election will be tough. Votes will need to be earned. Andy is the best chance of winning and that should override factional advantage or propping up one person."
👉 Listen to This Is Why on your podcast app 👈
Housing Secretary Steve Reed, a close ally of Sir Keir, has admitted the PM is "unpopular".
He told Sky News: "It's not a good week that we just had, let me put that on the table straight away.
"It reminds me of what went on under the Conservatives, and I think we need to draw that to a close as quickly as possible."
Asked if changing an unpopular leader was necessary to beat Reform UK at the next election, Reed replied: "The prime minister is unpopular, but each of the last four prime ministers, in turn, has been the most unpopular prime minister we've ever had."
The outbreak has been identified in the remote Ituri province, near the border with Uganda, where officials have recorded 246 suspected cases, according to the Africa Centres for Disease Control and Prevention (Africa CDC).
Most of the cases and deaths have been reported in the Mongwalu, Rwampara and Bunia health zones, the agency said on Friday.
The government said it has activated its public ​health emergency operations centre, strengthened epidemiological and
laboratory surveillance, and ordered the rapid deployment of response teams.
The Ebola virus spreads through bodily fluids, including blood, vomit and semen, and can cause severe and often fatal illness.
Africa CDC has also raised concerns over the proximity of the outbreak to neighbouring Uganda and South Sudan.
"Africa CDC is concerned about the risk of further spread due to the urban context of Bunia and Rwampara" as well as "intense population movement" and mobility related to mining in the affected areas, which are close to Uganda and South Sudan, the agency said in a statement.
"Given ‌the high population movement between affected areas and neighbouring countries, rapid regional coordination is essential," the statement added.
Read more from Sky News:
CIA chief visits Cuba
Zelenskyy vows response to Russian strikes
An emergency meeting involving health officials from DRC, Uganda and South Sudan, alongside UN agencies and other international partners, was due to take place on Friday to coordinate the response.
DRC has experienced 17 Ebola outbreaks since the disease was first identified in the country in 1976.
One of the deadliest outbreaks, between 2018 and 2020 in eastern Congo, killed more than 2,000 people.
The country's eastern regions are also facing ongoing violence involving armed groups, including the M23 rebel movement and the Islamic State-linked Allied Democratic Force, complicating efforts to contain the disease.
Dr Gabriel Nsakala, a public health professor involved in previous Ebola responses in DRC, said the country had extensive experience dealing with outbreaks but warned rapid action would be essential.
"In terms of training, people already know what they can do," he said.
"Now, the expertise and equipment need to be delivered quickly."
The 19-year-old is accused of a data protection offence. Police Scotland said he would appear at Hamilton Sheriff Court "at a later date".
The teenager's arrest and charge comes after the official and his family were placed under "police surveillance", according to the Scottish Football Association (SFA).
On Wednesday, Celtic kept their title hopes alive after they were awarded a late penalty by John Beaton in the 2-3 win. The decision drew widespread criticism.
Read more:
US influencer charged with assault
Can Hearts FC win the title at Celtic Park?
Penalising Motherwell midfielder Sam Nicholson for handball in a stoppage-time VAR review, allowed Celtic to cut the gap on Scottish Premiership leaders Hearts to one point.
On Saturday, the two remaining title contenders will play each other in a final-day decider.
Even when liquidated Rangers had to start again in the fourth division in 2012, Celtic was still always ending the season at the summit without a serious challenger.
Jeopardy had to be found elsewhere in the Premiership or down the leagues.
Not, finally, this most captivating of seasons. One group of players has led the way since September, but they are the gatecrashers from Edinburgh.
Whether Heart of Midlothian could hold on to the lead has been gripping for the game, agonising for Derek McInnes' side.
But they could leave Celtic Park this afternoon having broken up the duopoly.
The hope will be for a day about football, without rancour between fans or threats to referees.
With Hearts holding a one-point advantage, just avoiding defeat to Celtic will seal their first title since 1960, in a finale for the ages.
It has been so long since the trophy last ended the season outside Glasgow that the win was masterminded by pre-Manchester United Alex Ferguson with Aberdeen in 1985.
Hearts will not want a reminder of the following season, the last time they came within touching distance of glory, only to lose out to Celtic on the final day.
No wonder so many scoffed at betting tycoon Tony Bloom's claim last June on buying into Hearts that he could disrupt the dominance.
Not even he imagined it could happen this quickly, evoking memories of Leicester's 5,000-1 Premier League title upset a decade ago.
And it's happened without outspending Celtic and Rangers, albeit benefiting from an unusual season of simultaneous struggles for both of the Old Firm.
There has not even been enough time for Mr Bloom to fully implement the analytical expertise that has served Brighton so well in the Premier League.
Separated by a border, the financial disparities between the Premier League and Scottish Premiership are stark.
While buying 29% of Hearts cost Mr Bloom £9.86m, Brighton would be worth hundreds of millions. And while Brighton generated £222m last season, Hearts banked just £24.4m.
That Celtic were making almost £144m at the same time highlights the gulf within Scottish football, too.
There are Celtic and Rangers with 55 championships apiece, followed in the roll of honour by Hearts, Aberdeen and Hibernian in joint third with only four titles each.
So today is about providing hope to fans - just as Leicester did - that one day it might finally come good for your team and you'll be the ones with the parade.
Fans will also reflect on the journey and the torment.
The chance to be crowned champions of Scotland would have seemed unimaginable 12 years ago when just surviving as a club was the priority.
Read more:
Scottish Premiership title to be decided in final-day clash
Man charged after Motherwell v Celtic referee's details leaked
"Can we keep ripping the script up?" Mr McInnes wondered on the eve of the trip to Celtic. "We have ripped the script up this season and I think from the first game of the season, nobody would have anticipated that we could be in this position."
It's why Hearts go to Celtic bullish, with belief this will be their day, their time to show you do not have to be weighed down by the baggage of expectation that a Scottish season begins with one question: will it be the year of Celtic or Rangers?
This has been Heart of Midlothian's year, even before any silverware is handed out.
Could Eins, Zwei, Drei be catchy enough, weird enough, to finally end 29 years of hurt? Or will it be the familiar chorus of "nul points"?
And who exactly is the man fronting up for Britain in Vienna on Saturday?
Look Mum No Computer is the stage name of Lincolnshire-born YouTuber and electro musician Sam Battle, who started making videos more than a decade ago.
He's pulled in a hefty 85 million views across social media since then and has a combined 1.4 million subscribers.
Not content with your standard Casio keyboard, Battle found a following through his love of vintage electro gear and putting together unusual instruments.
These include an organ fashioned from dozens of Furbies (the cult 90s toy), a Star Wars Lego droid orchestra, and a synthesizer made with 48 Nintendo Game Boys.
He even has his own museum in Ramsgate displaying his Frankenstein-esque creations and other "obsolete and experimental technology".
Videos on YouTube show him darting between electro gear at small one-man live shows - and earlier this year he played a gig at Berlin's famed techno club Berghain.
The 37-year-old is set to use his "mega synth" - to the untrained eye, a keyboard on a huge circuit board - when he belts out the track in the Austrian capital later.
He told Sky News' Katie Spencer he wrote the song in about 12 hours.
"I think there's just a certain Eurocentric feel that we're trying to bring into it, hence the chorus [Eins, zwei, drei, Darlin', I need something salty, Eins, zwei, drei, With a slice of pepperoni]."
While it might not rival Bob Dylan's greatest prose, UK fans will be hoping the song tickles Eurovision's taste for the quirky and catchy.
The Daily Telegraph called it a "synth-heavy banger that seems precision-engineered to appeal to the song contest's fan", while The Independent described it as "very, very English in a way that's both horrendously embarrassing and oddly charming".
Read more:
Israel qualifies for Eurovision Song Contest final
Less camp, more conservative - Russia's alternative Eurovision
Battle says he spent hours "drilling thousands of holes into aluminium" for the kit he's using on stage, and "soldered for multiple hours until the baby came" [he's also a new dad].
He's pushed back against any suggestion he's just doing it for a laugh or to gain more subscribers, insisting he's taking it "very seriously" and has "always been a massive Eurovision fan".
The last time the UK won the show was with Katrina And The Waves in 1997, the same year Tony Blair became prime minister, Princess Diana died, and Britain handed Hong Kong back to China.
Whether it's bad songs, underwhelming performances, or even punishment over Brexit - as some have claimed - recent results have mostly been dire.
The UK finished last in 2019 with Michael Rice, and the same again in 2021, when James Newman scored zero points.
Mae Muller finished second last in 2023, 18th with Olly Alexander in 2024, and 19th last year when girl group Remember Monday got zero points from the public.
Sam Ryder is the notable exception, whose song Space Man flirted with glory in 2022 but ended up second, the UK's best result in more than two decades.
Fingers crossed for tonight then, but home fans will likely be keeping very modest expectations - some bookies have the UK at 150/1 to win.